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http://dspace.nuph.edu.ua/handle/123456789/19575| Title: | The synthesis and antimicrobial properties of new 2-(R-phenylimino)-1,3-thiazoline derivatives containing the N-methylpiperazine moiety |
| Authors: | Yeromina, H. O. Demchenko, N. V. Демченко, Н. В. Єрьоміна, Г. О. Еремина, А. А. Kiz, O. V. Кизь, О. В. Кізь, О. В. Yeromina, Z. G. Еремина, З. Г. Єрьоміна, З. Г. Demchenko, S. |
| Keywords: | 2-(R-phenylimino)-1,3-thiazoline;N-methylpiperazine;Hantzsch synthesis;antimicrobial activity;sulfate-reducing bacteria |
| Issue Date: | 2019 |
| Bibliographic description (Ukraine): | The synthesis and antimicrobial properties of new 2-(R-phenylimino)-1,3-thiazoline derivatives containing the N-methylpiperazine moiety / H. O. Yeromina, N. V. Demchenko, O. V. Kiz, Z. G. Ieromina, S. Demchenko // Chemistry & Chemical Technology. - 2019. - Vol. 13, № 2. - Р. 150-156. |
| Abstract: | New derivatives of N-(R-phenyl)-3-(4-methyl1-piperazinyl)-1,3-thiazole-2(3H)- imine with the medium to high yields were synthesized by the Hantzsch reaction in the ethanol medium. The structure of target compounds was confirmed by elemental analysis and NMR spectroscopy. The antimicrobial activity of 1,3-thiazoline derivatives with the N-methylpiperazine moiety against sulfate-reducing bacteria of Desulfovibrio sp. М.4.1 strain was studied. It was found that substances containing the halo- and unsubstituted phenyl fragment in the position 4 of the thiazoline cycle showed the potent antimicrobial activity. |
| URI: | http://dspace.nuph.edu.ua/handle/123456789/19575 |
| Appears in Collections: | Наукові публікації кафедри фармацевтичної хімії |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Стаття Chem. Chem. Technol. Vol. 13, No. 2, pp. 150–156. 06 2019.pdf | 257,94 kB | Adobe PDF | View/Open |
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