Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на этот ресурс:
http://dspace.nuph.edu.ua/handle/123456789/19954| Название: | LC-MS/MS method development and validation for the determination of cardiazol in human plasma |
| Авторы: | Drapak, I. V. Zimenkovsky, B. S. Perekhoda, L. O. Kovalenko, S. M. Logoyda, L. Драпак, І. В. Зіменковський, Б. С. Перехода, Л. О. Коваленко, С. М. Логойда, Л. |
| Ключевые слова: | LC-MS/MS;Cardiazol;Human plasma;Validation;Pharmacokinetic studies |
| Дата публикации: | 2019 |
| Издательство: | International Journal of Applied Pharmaceutics |
| Библиографическое описание: | LC-MS/MS method development and validation for the determination of cardiazol in human plasma / I. V. Drapak, B. S. Zimenkovsky, L. O. Perekhoda, S. M. Kovalenko, L. Logoyda // Int. J. App. Pharm. – 2019. – Vol. 11. – Р. 380-385. |
| Краткий осмотр (реферат): | The main purpose of this study was to develop a simple, precise, rapid and accurate method for the quantification of cardiazol in human plasma. |
| Описание: | The total chromatographic run time was 2.5 min and the elution of cardiazol and IS (difenoconazole) occurred at ~2.15 and 1.98 min, respectively. A linear response function was established at 1-100 ng/ml for cardiazol and difenoconazole in human plasma. The % mean recovery for cardiazol in LQC, MQC and HQC was 102.8 %, 100.3 % and 95.9 %. The lowest concentration with the RSD<20% was taken as LLOQ and was found to be 1.10 ng/ml for cardiazol. The % accuracy of LLOQ samples prepared with the different biological matrix lots was found 109.7 %, which were found within the range of 80.00-120.00 % for the seven different plasma lots. % CV for LLOQ samples was observed as 11.9 %, which are within 20.00% of the acceptance criteria. The within-run coefficients of variation ranged between 0.311 % and 0.601 % for cardiazol. The within-run percentages of nominal concentrations ranged between 99.80 % and 100.41 % for cardiazol. The between-run coefficients of variation ranged between 0.332 % and 0.615 % for cardiazol. The between-run percentages of nominal concentrations ranged between 98.18 % and 101.21 % for cardiazol. |
| URI (Унифицированный идентификатор ресурса): | http://dspace.nuph.edu.ua/handle/123456789/19954 |
| Располагается в коллекциях: | Наукові публікації кафедри медичної хiмiї |
Файлы этого ресурса:
| Файл | Описание | Размер | Формат | |
|---|---|---|---|---|
| 33482-Article Text-161101-1-10-20190708.pdf | 300,35 kB | Adobe PDF | Просмотреть/Открыть |
Все ресурсы в архиве электронных ресурсов защищены авторским правом, все права сохранены.