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Title: | Synthesis of new Mannich bases containing 1,2,4-triazole and piperidine moiety |
Authors: | Yeromina, H. O. Perekhoda, L. O. Yeromina, Z. G. Schepochkina, S. S. Demchenko, A. M. Еремина, А. А. Єрьоміна, Г. О. Перехода, Л. О. Єрьоміна, З. Г. Еремина, З. Г. Щепочкина, С. С. Демченко, А. М. |
Issue Date: | 2019 |
Bibliographic description (Ukraine): | Synthesis of new Mannich bases containing 1,2,4-triazole and piperidine moiety / H. O. Yeromina, L. O. Perekhoda, Z. G. Ieromina, S. S. Schepochkina, A. M. Demchenko // Science and Practice 2019 : 10th International Pharmaceutical Conference, Kaunas, November 15th, 2019. - Kaunas, 2019. - Р. 95. |
Abstract: | The 1,2,4-triazole nucleus forms the basis of a series of compounds of both therapeutic and chemical interest. 1,2,4-triazole derivatives possesses antiviral, antibacterial, antitumor, antidepressant, antihypertensive activity etc. Substituted 1,2,4-triazole-3-thiones can be used as substrats containing active hydrogen for Mannich reaction. Mannich reaction is important for the construction of nitrogen-containing compounds. The literature studies enlighten the fact that Mannich bases are very reactive and recognized to possess potent diverse activities like anti-inflammatory, antibacterial, anti-HIV, antimalarial, antitubercular, analgesic, antipsychotic activities and so forth. In view of this, the aim of our work was to synthesize new Mannich bases in order to find biologically active substances. |
Description: | New 5-(4-bromophenyl)-4-(R-phenyl)-2-(1-piperidylmethyl)-1,2,4-triazole-3- thiones were synthesized and its structure and purity were confirmed by data of modern physicochemical methods of analysis. The synthesis of substances in this series of derivatives continues. |
URI: | http://dspace.nuph.edu.ua/handle/123456789/20791 |
Appears in Collections: | Наукові публікації кафедри медичної хiмiї |
Files in This Item:
File | Description | Size | Format | |
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10thСonf_Литва_15.11.19_Mannich bases cont 1,2,4-triazole, piperidine.pdf | 810,77 kB | Adobe PDF | View/Open |
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