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http://dspace.nuph.edu.ua/handle/123456789/21041
Полная запись метаданных
Поле DC | Значение | Язык |
---|---|---|
dc.contributor.author | Vlasov, S. V. | - |
dc.contributor.author | Borisov, A. V. | - |
dc.contributor.author | Kovalenko, S. M. | - |
dc.contributor.author | Chernykh, V. P. | - |
dc.contributor.author | Osolodchenko, T. P. | - |
dc.contributor.author | Власов, С. В. | - |
dc.contributor.author | Борисов, О. В. | - |
dc.contributor.author | Коваленко, С. М. | - |
dc.contributor.author | Черних, В. П. | - |
dc.contributor.author | Осолодченко, Т. П. | - |
dc.contributor.author | Власов, С. В. | - |
dc.contributor.author | Борисов, А. В. | - |
dc.contributor.author | Коваленко, С. Н. | - |
dc.contributor.author | Черных, В. П. | - |
dc.contributor.author | Осолодченко, Т. П. | - |
dc.date.accessioned | 2020-01-14T20:11:02Z | - |
dc.date.available | 2020-01-14T20:11:02Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Synthesis and antimicrobial activity study of thieno[3,2-e][1,2,4]triazolo [4,3-c]pyrimidin-3(2H)-one derivatives / S. V. Vlasov, A. V. Borisov, S. M. Kovalenko, V. P. Chernykh, T. P. Osolodchenko // Journal of Chemical and Pharmaceutical Research. - 2014. - № 6 (8). - Р. 170-176. | uk_UA |
dc.identifier.uri | http://dspace.nuph.edu.ua/handle/123456789/21041 | - |
dc.description.abstract | Cyclization 4-hydrazinothieno[2,3-d]pyrimidines with 1,1'-carbonyldiimidazole was proposed as the novel and highly effective approach for synthesis of the series of thieno[3,2-e][1,2,4]triazolo[4,3-c]pyrimidin-3(2H)-ones. Heterocyclic systems obtained were modified by alkylation with chloroacetamides (DMF-K2CO3), and produced 2(3-oxothieno[3,2-e][1,2,4]triazolo[4,3-c]pyrimidin-2(3H)-yl)-N-acetamides. Antimicrobial activity screening for all of the compounds obtained has been performed by the agar well diffusion method. The highest antimicrobial activity was determined for ethyl 9-methyl-3-oxo-2,3-dihydrothieno[3,2-e][1,2,4]triazolo[4,3-c]pyrimidine-8-carboxylate 2d, which showed the activity against Proteus vulgaris similar to Synthomycine. Some of the compounds also showed better activity than Metronidazole against the strain of Candida albicans fungi. | uk_UA |
dc.language.iso | en | uk_UA |
dc.subject | thiophene | uk_UA |
dc.subject | pyrimidine | uk_UA |
dc.subject | carbonyldiimidazole | uk_UA |
dc.subject | triazole | uk_UA |
dc.subject | antimicrobial activity | uk_UA |
dc.title | Synthesis and antimicrobial activity study of thieno[3,2-e][1,2,4]triazolo [4,3-c]pyrimidin-3(2H)-one derivatives | uk_UA |
dc.type | Article | uk_UA |
Располагается в коллекциях: | Наукові публікації В. П. Черних |
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Файл | Описание | Размер | Формат | |
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335.pdf | 133,67 kB | Adobe PDF | Просмотреть/Открыть |
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