Please use this identifier to cite or link to this item:
http://dspace.nuph.edu.ua/handle/123456789/21041
Title: | Synthesis and antimicrobial activity study of thieno[3,2-e][1,2,4]triazolo [4,3-c]pyrimidin-3(2H)-one derivatives |
Authors: | Vlasov, S. V. Borisov, A. V. Kovalenko, S. M. Chernykh, V. P. Osolodchenko, T. P. Власов, С. В. Борисов, О. В. Коваленко, С. М. Черних, В. П. Осолодченко, Т. П. Власов, С. В. Борисов, А. В. Коваленко, С. Н. Черных, В. П. Осолодченко, Т. П. |
Keywords: | thiophene;pyrimidine;carbonyldiimidazole;triazole;antimicrobial activity |
Issue Date: | 2014 |
Bibliographic description (Ukraine): | Synthesis and antimicrobial activity study of thieno[3,2-e][1,2,4]triazolo [4,3-c]pyrimidin-3(2H)-one derivatives / S. V. Vlasov, A. V. Borisov, S. M. Kovalenko, V. P. Chernykh, T. P. Osolodchenko // Journal of Chemical and Pharmaceutical Research. - 2014. - № 6 (8). - Р. 170-176. |
Abstract: | Cyclization 4-hydrazinothieno[2,3-d]pyrimidines with 1,1'-carbonyldiimidazole was proposed as the novel and highly effective approach for synthesis of the series of thieno[3,2-e][1,2,4]triazolo[4,3-c]pyrimidin-3(2H)-ones. Heterocyclic systems obtained were modified by alkylation with chloroacetamides (DMF-K2CO3), and produced 2(3-oxothieno[3,2-e][1,2,4]triazolo[4,3-c]pyrimidin-2(3H)-yl)-N-acetamides. Antimicrobial activity screening for all of the compounds obtained has been performed by the agar well diffusion method. The highest antimicrobial activity was determined for ethyl 9-methyl-3-oxo-2,3-dihydrothieno[3,2-e][1,2,4]triazolo[4,3-c]pyrimidine-8-carboxylate 2d, which showed the activity against Proteus vulgaris similar to Synthomycine. Some of the compounds also showed better activity than Metronidazole against the strain of Candida albicans fungi. |
URI: | http://dspace.nuph.edu.ua/handle/123456789/21041 |
Appears in Collections: | Наукові публікації В. П. Черних |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.