Development of Safe Dermotologic Preparation with Account of Natural Constituens of Skin

Abstract

Recently incidence and prevalence of inflammatory skin diseases became very high. For example, in some countries up to 25% of the population suffers from the dermatosis. The incidence rate of dermatosis among the children far outweighs the incidence rate of dermatosis among the adults. Modern therapy of dermatosis is aimed to suppress inflammatory process and immune response. Main preparations for local treatment of dermatosis are glucocorticosteroids (GCS) that have antiinflammatory, immunosuppressive, antipruritic action; conversely these medications can cause steroid adermotrophia due to long term usage. Vasoconstrictor effect of GCS, suppressing proliferative reparative processes, reinforcement of dystrophic changes of collagen and elastic fibres is a signifficant in the development of adermotrophia. Therefore skin looses elasticity, it becomes hyposthenic, dry and thin. Skin barrier function disturbs that results in hyperpermeability of epidermis for toxins, microorganisms. That's why up to date treatment of dermatosis is paid particular attention. It is known that disturbance of hydrolipidic film is caused by lack of lipids in it (in particular, ceramides), that results in skin laxity, increase in transepidermal water loss, penetration of allergens that causes development of irritation. In this regard usage of medications for treatment of dermatosis that heal and restore skin barrier function is very essential. Thus, the problem of treatment of dermatosis remains unaddressed that gives evidence of practicability of the development of new efficient and safe preparation for dermatology. The goal of this work was investigation of atrophic action of the developed combination dermatologic preparations in order to increase safety of glucocorticosteroid therapy through the introduction of ceramides into the composition of preparations.