Choice of the preservative in the composition of vaginal gel with resveratrol and hyaluronic acid for treatment of urogenital symptoms in the climax period

Abstract

Hormonal disorders in women in the climaх period are usually accompanied by a series of unpleasant symptoms from the genital and urinary system such as dryness and inflammation of the mucous membranes of the genitals, painful urination, and the like. These affect the quality of daily life of a woman and require treatment. Rational is the use of local semisolid drugs in the form of gels based on plant material of phytoestrogenic action. They have a localized mild effect and exhibit no systemic side effects, unlike synthetic hormonal drugs. Previous studies have found the optimal composition and technology of vaginal gel with resveratrol, which exhibits phytoestrogenic and anti-inflammatory effects, and hyaluronic acid, which moisturizes and promotes the regeneration of mucous tissues [1,2]. Microbial contamination of a product is possible in the process of production, storage and use, which can shorten the shelf life and adversely affect the safety profile of the drug. Therefore, an important criterion for evaluating the quality of a medicinal product is microbiological purity [3]. To ensure stability and quality of the drug throughout the shelf life, a preservative must be added to the gel. To date, it is relevant to use combined non-paraben preservatives, which have a wide range of antibacterial action and are safe for the human body. The purpose of the study was to determine and compare the antimicrobial effectiveness of preservatives in the composition of the vaginal gel.