Irrational (Difficult) Prescriptions in Extemporaneous Compounding: Rationing and Preparation

Abstract

The work represents the data about irrational (difficult) prescriptions in extemporaneous compounding, their rationing and preparation. The given information is released according to the literary data analysis. By studying these literary data, we lead and summarize some examples of irrational (difficult) prescriptions in different medicinal forms. Extemporal medicines based on the principles of Good Prescribing Practices (GPRP) are the leading criteria for the effectiveness of health systems in the world's leading countries. There is no uniform approach in questions of rationalization of the prescribed medicines in the regulatory sphere of the health care system, has a direct negative influence on the quality and effectiveness of the provided pharmacotherapy. Material and methods. The part represents information about the works of well-known scientists about the most frequently encountered inconvenient cases of the extemporaneous formulation and the reasons for their formation on individual prescriptions, and possible ways of their elimination. Results and discussion. Some examples of irrational (difficult) prescriptions presented in literary sources were shown. Difficulties can arise when prescribing medicinal substances that are not soluble in prescribed solvent, at concentrations exceeding their solubility, due to the precipitation of the precipitate in the usual order of their mixing or dissolution, etc. The ability to prepare extemporaneous dosage forms for irrational (difficult) prescriptions with the use of special techniques and to recognize incompatible combinations in prescriptions characterizes the professionalism of pharmacists, prevents possible mistakes and promotes the release of only high-quality extemporaneous medicines to the patient. The normative substantiation of the problem of pharmaceutical incompatibilities, in our opinion, will increase the professional knowledge of pharmacists about the physical phenomena and chemical interactions that may occur in dosage forms, and will guide them in practical activities in deciding on the choice of a rational method for preparation of the extemporaneous medicine. The analysis of the main approaches to the organization of rational prescribing of extemporal medicines in European countries has shown the need for the introduction of guidelines and standards for health professionals; education and information organizations; conducting monitoring of recipes and prescription drugs; improvement of financial motivation of doctors.