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http://dspace.nuph.edu.ua/handle/123456789/21536| Назва: | Synthesis of 2-(4-aryl(adamantyl)-2-phenylіmіnothіazol-3-yl)-ethanol derivatives and prediction of their biological activity |
| Автори: | Yeromina, H. O. Drapak, I. V. Perekhoda, L. O. Yaremenko, V. D. Demchenko, A. M. |
| Теми: | 1,3-thiazole derivatives;synthesis;spectral characteristics;«drug-likeness»;virtual screening |
| Дата публікації: | 2016 |
| Бібліографічний опис: | Synthesis of 2-(4-aryl(adamantyl)-2-phenylіmіnothіazol-3-yl)-ethanol derivatives and prediction of their biological activity / H. O. Yeromina, I. V. Drapak, L. O. Perekhoda, V. D. Yaremenkom, A. M. Demchenko // Der Pharma Chemica. – 2016. – № 8 (3). – P. 64-70. |
| Короткий огляд (реферат): | The synthesis of new 2-(4-aryl(adamantyl)-2-phenylіmіnothіazol-3-yl)-ethanol derivatives has been carried out. The structures and purity of synthesized compounds were verified on the basis of elemental analysis, 1Н NMRspectroscopy and chromatography-mass spectrometry. To optimize the pharmacological screening of 2-(4-aryl(adamantyl)-2-phenylіmіnothіazol-3-yl)-ethanol derivatives «drug-like» parameters have been calculated and simulation of biological properties has been done. It was established that 13 synthesized compounds comply with Lipinski's Rule of Five and can be recommended for experimental biological tests. Based on data PASS-prediction as priority directions for experimental trials screening for anti-ischemic and anti-inflammatory activity has been chosen. The most perspective substances for experimental biological tests were elected. |
| Опис: | The synthesis of undescribed in the literature 2-(4-R-aryl(adamantyl)-2-phenylіmіnothіazol-3-yl)-ethanol derivatives was сarried out for the purpose of searching for new biologically active compounds and the structure of synthesized compounds were confirmed by elemental analysis, 1Н NMR- and chromatomass-spectra |
| URI (Уніфікований ідентифікатор ресурсу): | http://dspace.nuph.edu.ua/handle/123456789/21536 |
| Розташовується у зібраннях: | Наукові публікації кафедри фармацевтичної хімії |
Файли цього матеріалу:
| Файл | Опис | Розмір | Формат | |
|---|---|---|---|---|
| DPC-2016-8-3-64-70.pdf | 125,53 kB | Adobe PDF | Переглянути/відкрити |
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