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http://dspace.nuph.edu.ua/handle/123456789/25063
Название: | Dynamics of biochemical markers of the connective tissue metabolism in the blood of rats after insertion of steel implants with diamond-like carbon coating into the femur |
Авторы: | Makarov, V. B. Morozenko, D. V. Gliebova, K. V. Danylchenko, S. I. |
Ключевые слова: | biochemical markers;bone tissue;diamond-like carbon coating;implantation;osteointegration |
Дата публикации: | 2021 |
Библиографическое описание: | Dynamics of biochemical markers of the connective tissue metabolism in the blood of rats after insertion of steel implants with diamond-like carbon coating into the femur / V. B. Makarov, D. V. Morozenko, K. V. Gliebova, S. I. Danylchenko // Bangladesh Journal of Medical Science. - 2021. - Vol. 20, № 01. - Р. 81-85. |
Краткий осмотр (реферат): | Objective: It is known that the regeneration of bone tissue after implantation of any structure sdepends on the coating of their surface. Therefore, the research of the influence of steel implants with diamond-like carbon coating on regeneration of bone tissue in the dynamics after implantation is a topical issue. Material and Methods: The study was conducted on 61 male rats, 5 of them were intact animals. There were also 2 groups of rats with 28 animals in each group (the 1st group was the control one where implants were without diamond-like carbon coating, the 2nd group was experimental where the implants were without coating). We determined the content of glycoproteins, chondroitin sulfates, alkaline phosphatase, total calcium, oxyproline and osteocalcin in the blood of rats on the 7th, 14th, 30th and 90th days after implantation. Results and Discussion: Group 2 rats had a faster osteointegration compared with the group 1 rats, which was manifested by the normalization of biochemical markers of bone metabolism (glycoproteins, chondroitinsulfats, oxyproline and osteocalcin) on the 90th day of an experiment. Conclusion: Using steel implants with diamond-like carbon coatings showed that the content of glycoproteins and chondroitin sulfates increased only on the 7th day; oxyproline and osteocalcin increased on the 7th, 14th and 30th days after implantation; on the 90th day the rates of these biochemical markers reached the norm, indicating a high efficiency of osteointegration. |
URI (Унифицированный идентификатор ресурса): | http://dspace.nuph.edu.ua/handle/123456789/25063 |
ISSN: | ISSN 2223-4721 eISSN 2076-0299 |
Располагается в коллекциях: | Наукові публікації кафедри бiологiчної хiмiї та ветеринарної медицини |
Файлы этого ресурса:
Файл | Описание | Размер | Формат | |
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81-85.pdf | 370,25 kB | Adobe PDF | Просмотреть/Открыть |
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