Antimicrobial properties of morpholine-containing 1,3-thiazol-2(3H)-imine derivatives

Abstract

According to the results obtained, tested morpholine-containing 1,3-thiazol-2(3H)-imine derivatives have a high potency as antimicrobial agents. The tested substances with methoxy and dimethoxy substituents showed high sensitivity to gram-positive microorganisms − Staphylococcus aureus and Bacillus subtilis with growth inhibition zones 24-26 mm. The substance with the ethoxy substituent showed slightly lower activity − the growth inhibition zone was 20-22 mm. Against gram-negative microorganisms (Pseudomonas aeruginosa and Proteus vulgaris) all substances demonstrated moderate antibacterial activity with growth inhibition zones of 16-18 mm and fungicidal activity against the fungus Candida albicans with growth inhibition zones of 20-21 mm. These data indicate the prospects for further studies of these substances.