Synthesis and diuretic activity of novel 5-amino-1,3,4-thiadiazole- 2-thiol derivatives

Abstract

To summarize, in an attempt to obtain an efficacious and non-toxic diuretic, we have designed and synthesized a series of 1,3,4-thia-diazole-bearing derivatives. Some derivatives have demonstrated a high level of diuretic action with satisfactory kaliuretic, saluretic, and natriuretic properties. Additional research on the mechanisms of activity of these compounds and modification is underway. The results obtained from the in vivo diuretic studies demonstrate the potential of searching for diuretic agents among 5-benzylthio-1,3,4-thi-adiazol-2-amine derivatives.