Search for prospective biologically active substances of antituberculosis асtion in the series of pyrazin-2- ylamides 1-r-4-hydroxy-2-oxo-1,2-dihydroquinoline-3- carboхylic acids

Abstract

The search for new biologically active substances and the creation of medicines on their basis, which, in terms of their effectiveness and safety, met the requirements of modern times as much as possible, is one of the most pressing problems of pharmaceutical science. An efficient and reliable way of solving such problems was the optimization of the first selected leading structures. It carried out by means of a purposeful chemical modification, which is simple in execution, due to which it has found wide use in various fields of science and technology, including in medicinal chemistry. Derivatives of 4-hydroxy-2-oxoquinoline-3- carboxamide, which is widespread in nature, are of particular interest in this regard. The extremely wide range of biological properties inherent in this compound and, what is especially important, the practically unlimited synthetic potential make them very convenient objects for research of this kind. The experience accumulated in this case and the identification of structural and biological regularities formed the basis of this work, which is actually a fragment and a logical continuation of a large complex study on the study of methods of synthesis, structure, chemical transformations and pharmacological properties of various 4-hydroxy-2-oxoquinoline-3- carboxamides.