Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на этот ресурс: http://dspace.nuph.edu.ua/handle/123456789/26696
Название: Development of a therapeutic agent with vegetable extract in the form of tablets for gastroenterology
Другие названия: Створення лікарського засобу з рослинним екстрактом у формі таблеток для гастроентерології
Авторы: Bezkrovna, K. S.
Shulga, L. I.
Yakuschenko, V. A.
Piminov, O. F.
Безкровна, К. С.
Шульга, Л. І.
Якущенко, В. А.
Пімінов, О. Ф.
Ключевые слова: dry extract of Sanguisorba officinalis roots;tablets;technology;gastroenterology;antimicrobial action;родовика коренів екстракт сухий;таблетки;технологія;гастроентерологія;антимікробна дія
Дата публикации: 2021
Библиографическое описание: Development of a therapeutic agent with vegetable extract in the form of tablets for gastroenterology / K. S. Bezkrovna, L. I. Shulga, V. A. Yakuschenko, O. F. Piminov // Annals of Mechnikov Institute. - 2021. - № 2. - P. 16-20.
Краткий осмотр (реферат): There is a progressive increase in the incidence of inflammatory diseases of the upper gastrointestinal tract. Resistance of microorganisms to most antibacterial drugs prescribed to gastroenterological patients has formed the need to search for new therapeutic agents, including extracts. Dry extract was obtained on the basis of Sanguisorba officinalis roots selected as the object of study. Previous biological studies have proven its gastroprotective and antimicrobial action, and a survey of pharmacy experts showed the commitment of consumers to drugs in tablets as the most popular dosage form. Therefore, the aim of the study was to develop drugs in the form of tablets for gastroenterology, based on the dry extract of Sanguisorba officinalis roots, which has antimicrobial action. Materials and methods. Objects of study involved dry extract of Sanguisorba officinalis roots and excipients for tableting. According to the methods of the State Pharmacopoeia of Ukraine, the pharmaco technological properties of tablets (homogeneity of mass, abrasion, resistance of tablets to crushing, disintegration time, average weight) were studied and their appearance was visually determined. Antimicrobial activity was studied of the Biochemistry and Biotechnology Laboratory of the State Institution «Mechnikov Institute of Microbiology and Immunology of NAMS of Ukraine» under the direction of Candidate of Biological Sciences Osolodchenko T. P. by the method of double serial dilutions in nutrient broth with statistical processing of data results by Excel software. The technology of obtaining tablets on the basis of dry extract of Sanguisorba officinalis roots under the conditional name «Gastro-San» by the method of direct compression with the technological scheme of their production was developed. The pharmaco-technological properties of tablets were studied and the compliance of the obtained indicators with the requirements of SPU was established Studies of the antimicrobial properties of Gastro-San tablets against reference test strains (S. aureus ATCC 25923, E. coli ATCC 25922, B. subtilis ATCC 6633, P. aeruginosa ATCC 27853, P. vulgaris ATCC 4636 and Candida fungi) and clinical strains of microorganisms (S. aureus 57, E. coli 23, K. pneumonia 13, P. vulgaris 18, C. freundii 39, E. cloacae 54, E. coli 14 (hemolytic), S. enteritidis 1, S. typhimurium 2, S. flexneri 3, P. mirabilis 33) proved antimicrobial action of the developed tablets. Conclusions. The technology of obtaining Gastro-San tablets by direct compression has been developed. Assessment of pharmaco-technological indicators of the developed tablets was carried out and conformity of quality of Gastro-San tablets to requirements of article «Tablets» of the State Pharmacopoeia of Ukraine was established. The antimicrobial action of the drug Gastro-San has been established, which indicates the prospects of including the developed drug in the complex therapy gastrointestinal diseases as an antimicrobial agent.
URI (Унифицированный идентификатор ресурса): http://dspace.nuph.edu.ua/handle/123456789/26696
Располагается в коллекциях:Наукові публікації кафедри фармацевтичних технологій та забезпечення якості ІПКСФ

Файлы этого ресурса:
Файл Описание РазмерФормат 
16-20.pdf292,48 kBAdobe PDFПросмотреть/Открыть


Все ресурсы в архиве электронных ресурсов защищены авторским правом, все права сохранены.