Synthesis and prediction of nootropic activity of substituted 4-(aminomethyl)-1- benzylpyrrolidin-2-ones

Abstract

The pyrrolidone family of chemicals (2-oxopyrolidine) has been the subject of research for over three decades. Experimental and clinical work first focused on their so-called nootropic effects; later, the possibilities of neuroprotection after stroke and use as antiepileptic drugs appeared. Considering the structural similarity with known nootropics, further studies of new substituted 4-(aminomethyl)-1- benzylpyrrolidin-2-one as a prototype of innovative drugs of nootropic action is a fairly justified approach to targeted search. An important strategy of modern research is to use the methodology of binding new ligands to appropriate biological targets (molecular docking). The results of this methodology can be used in planning experimental screening.