Prediction of antitumor activity of 3-substituted quinazolinone derivatives synthesized in one-pot method catalyzed by Bi(OTf)3

Abstract

INTRODUCTION: Nitrogen-containing heterocycles are broadly dispersed in nature and are basic to life, assuming an indispensable job in the digestion of every single living cell. 4(3H)-Quinazolinones have risen as a significant class of nitrogen containing heterocycles that have pulled in critical manufactured intrigue on account of their pharmacological and remedial properties, for example, antibacterial, antifungal, antimalarial, antihypertensive, anticonvulsant, for treatment Parkinsonism, antihistaminic and nearby sedative, pain relieving, mitigating antiviral and anticancer activities 1-10. Few quinazolinones have been accounted for as strong chemotherapeutic operators in the treatment of tuberculosis. For instance, 3-aryl-6,8-dichloro-2H-1,3-benzoxazine-2,4(3H)-diones and 3-arylquinazoline-,4(1H,3H)-diones were recommended as antimycobacterial agents11 and as antitubercular agents 12