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http://dspace.nuph.edu.ua/handle/123456789/28952| Title: | Pharmacological study of original extracts of corn silk |
| Authors: | Naboka, O. I. Набока, О. І. Vyshnevska, L. I. Вишневська, Л. І. Pasynchuk, I. Filiptsova, O. V. Філіпцова, О. В. Tkachenko, O. V. Ткаченко, О. В. Vislous, O. O. Віслоус, О. О. |
| Keywords: | corn silk extracts;lipid peroxidation;antioxidant activity;choleretic activity;acute toxicity;Drosophila melanogaster Meig. test system;hepatoprotector |
| Issue Date: | 2022 |
| Bibliographic description (Ukraine): | Pharmacological study of original extracts of corn silk / O. Naboka, L. Vyshnevska, I. Pasynchuk [et al.] // Scientific Journal «ScienceRise:Biological Science». – 2022. – Vol. 4 (33). – P. 10–17. |
| Description: | As can be seen from the given data, ECSE 50 % at a dose of 20 mg/kg showed a pronounced protective effect on the hepatotoxicity of TСM. Its use led to a probable restoration of the bile-forming function of the liver against the background of tetrachloromethane hepatitis: in response to an increase in the cholesterol content (by 43 %, p<0.05), the content of bile acids increased 2 times (p<0.05), as a result of which cholate -cholesterol ratioapproached the level of indicators of intact animals, the rate of bile secretion normalized. Based on the analysis of the results of the study, itcan be concluded, that in terms of bile-forming and choleretic activity on the tetrachloromethane hepatitis model, ECSE 50 % was not inferior to silibor and superior to quercetin (р<0.05).Conclusions.Biologically active substances of corn silk affect not only the diffusion and filtration processes of the liver parenchyma, but also the biosynthesis and transport of its organic components, that is, they affect the bile-forming function |
| URI: | http://dspace.nuph.edu.ua/handle/123456789/28952 |
| Appears in Collections: | Наукові публікації кафедри фармацевтичної хімії |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 271049-Article Text-626575-2-10-20230116.pdf | 459,83 kB | Adobe PDF | View/Open |
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