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http://dspace.nuph.edu.ua/handle/123456789/33175| Title: | Synthesis and nootropic activity prediction of some 4-(aminomethyl)-1-benzylpyrrolidin-2-one derivatives structurally related with nebracetam |
| Authors: | Perekhoda, Lina Suleiman, Marharyta Podolsky, Illya Semenets, Anton Kobzar, Natalia Yaremenko, Vitaliy Vislous, Оlga Georgiyants, Victoriya Kovalenko, Sergiy Перехода, Ліна Сулейман, Маргарита Подольський, Ілля Семенець, Антон Кобзар, Наталія Яременко, Віталій Віслоус, Ольга Георгіянц, Вікторія Коваленко, Сергій |
| Keywords: | synthesis;4-( aminomethyl)-1-benzylpyrrolidin-2-one;molecular docking;acetylcholine receptors;nootropic activity |
| Issue Date: | 2024 |
| Bibliographic description (Ukraine): | Synthesis and nootropic activity prediction of some 4-(aminomethyl)-1-benzylpyrrolidin-2-one derivatives structurally related with nebracetam / L. Perekhoda [et al.] // ScienceRise: Pharmaceutical Science. - 2024. - № 4 (50). - P. 23-34. |
| Abstract: | Search for new biologically active substances with improved nootropic parameters among analogues of 4-(aminomethyl)-1-benzylpyrrolidine-2-one (Nebracetam). |
| Description: | An effective method for synthesising analogues of 4-(aminomethyl)-1-R-benzylpyrrolidin-2-ones has been developed. The molecular docking revealed potential mechanisms of nootropic action of the synthesized derivatives as potential agonists and positive allosteric modulators of the muscarinic receptor. |
| URI: | http://dspace.nuph.edu.ua/handle/123456789/33175 |
| Appears in Collections: | Наукові публікації кафедри фармацевтичної хімії |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 310731-Article Text-718304-3-10-20240901.pdf | 1,51 MB | Adobe PDF | View/Open |
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