Development of a gel formulation for the treatment of rheumatoid arthritis

Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory disorder that affects joints, leading to pain, swelling, and eventual joint deformity. Traditional treatments often involve systemic medications that can cause unwanted side effects. Herbal remedies have long been used in folk medicine to alleviate symptoms of RA and other joint diseases. One such remedy is the marsh cinquefoil (Comarum palustre), known for its anti-inflammatory and analgesic properties. This study aims to develop a topical gel formulation containing marsh cinquefoil extract for treating rheumatoid arthritis and other inflammatory joint conditions. Using a gel base allows localized application, targeting the affected area while minimizing systemic exposure