Study of the poteintial anti-tuberculosis activity of derivatives of [3-(2-methoxyethyl)-4-oxo-3,4-dihydroquinazolin-2-yl]thioacetic acid by molecular docking

Abstract

Tuberculosis is a problem of humanity, and currently there is an epidemic of this disease, which is associated with the low sensitivity of M. tuberculosis to most antibiotics. Despite the fact that therapy requires about six months even if it is successful, tuberculosis is a curable disease. The problem of therapy is significantly complicated for resistant strains of tuberculosis. Therefore, much attention is paid to the development of new potentially effective antimicrobial agents to reduce the resistance of tuberculosis strains.