Theoretical studies on the anti-inflammatory activity of hyperoside with the cyclooxygenesa 2 enzyme

Abstract

Arachidonic acid and its metabolites (prostaglandins and leukotrienes) are important intracellular messengers which play an important role in pain and inflammation regulatory pathways. Cyclooxygenase-2 (COX-2) is the key enzyme in the biosynthesis of prostaglandins from aracidonic acid, which are key mediators of inflammation. COX-2 catalyzes the conversion of arachidonic acid to prostaglandin H2, the precursor of PGs and thromboxane. The aim of our study was to perform molecular docking of hyperoside with the COX-2 enzyme.