Theoretical studies on the anti-inflammatory activity of hyperecin with the nuclear factor - kB enzyme

Abstract

The nuclear factor κB (NF-κB) pathway has long been considered a prototypical proinflammatory signaling pathway, largely based on the role of NF-κB in the expression of proinflammatory genes including cytokines, chemokines, and adhesion molecules. NF-κB has long been considered a prototypical proinflammatory signaling pathway, largely based on the activation of NF-κB by proinflammatory cytokines such as interleukin 1 (IL-1) and tumor necrosis factor α (TNF- α). NF-κB has important roles in the pathogenesis of chronic inflammatory diseases such as rheumatoid arthrtitis.