Theoretical studies on the antioxidant activity of hyperecin with the NADPH oxidase enzyme

Abstract

The NADPH oxidase catalyze the deliberate production of reactive oxygen species (ROS) and are established regulators of redox-dependent processes across diverse biological settings. NADPH oxidases are present in phagocytes and in a wide variety of nonphagocytic cells. The enzyme generates superoxide by transferring electrons from NADPH inside the cell across the membrane and coupling them to molecular oxygen to produce superoxide anion, a reactive free-radical. So, NADPH oxidase is a crucial enzyme in developing oxidative stress. The aim of our study was to perform molecular docking of hyperecin with the NADPH oxidase enzyme.