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http://dspace.nuph.edu.ua/handle/123456789/35760| Title: | Rational design of multimodal antiepileptic agents based on the tetrazole framework of cenobamate |
| Authors: | Velhan, T. M. Severina, H. I. |
| Keywords: | cenobamate;tetrazole;antiepileptic agents;GABAА receptor;voltage-gated sodium channels;molecular modeling |
| Issue Date: | 2025 |
| Publisher: | НФаУ |
| Bibliographic description (Ukraine): | Velhan, T. Rational design of multimodal antiepileptic agents based on the tetrazole framework of cenobamate / T. M. Velhan, H. I. Severina. Механізми розвитку патологічних процесів і хвороб та їх фармакологічна корекція : матеріали VІІ наук.-практ. internet-конф. з міжнар. участю, м. Харків, 20 жовт. 2025 р. - Харків : НФаУ, 2025. - С. 60-61. |
| Abstract: | Epilepsy is a complex polyetiological neurological disorder characterized by a chronic predisposition of the brain to generate paroxysmal electrical activity, leading to recurrent seizures and cognitive–behavioral impairments. The pathophysiological basis of the disease lies in the imbalance between excitatory (glutamatergic) and inhibitory (GABAergic) processes in neuronal networks, resulting in neuronal hyperexcitability and impaired synaptic plasticity |
| URI: | http://dspace.nuph.edu.ua/handle/123456789/35760 |
| Appears in Collections: | Наукові публікації кафедри фармацевтичної хімії |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 95.Пат_фіз_жзовтень_2025_60-61.pdf | 642,23 kB | Adobe PDF | View/Open |
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