Comparison of multi-criteria optimization methods in pharmaceutical development

Abstract

Multi-criteria optimization is a key tool in pharmaceutical development. It is used to optimize technological processes, predict pharmacokinetics and pharmacodynamics, ensure stability and bioavailability of dosage forms, and comply with safety, quality, and regulatory requirements. It reconciles multiple, often conflicting criteria, supporting informed decision-making in drug development. This approach is particularly important for determining the composition and manufacturing technology of pharmaceutical products. It enables quantitative identification ofeffective excipient combinations and technological conditions to ensure required pharmaco-technological characteristics, including quality, efficacy, and safety. It formalizes the development process, enhances reproducibility, and reduces subjective influence, which is crucial for evidence-based pharmacy and regulatory compliance