Combined therapy with loratedine and Bupleurum aureum extract as a means of correction of immunoinflammatory and oxidative disorders in allergic rhinitis in immure rats

Abstract

Allergic rhinitis is one of the most common IgE-mediated diseases, characterized by the development of a systemic immunoinflammatory response, hyperproduction of IgE, activation of mast cells and eosinophils, as well as the release of inflammatory mediators, in particular histamine and proinflammatory cytokines. An important role in the pathogenesis of the disease is played not only by immune mechanisms, but also by oxidative stress, which increases mucosal damage and maintains the chronic course of the inflammatory process. Modern pharmacotherapy of allergic rhinitis is based mainly on the use of antihistamines, but their effectiveness is not always sufficient for the complete correction of immunoinflammatory and oxidative disorders. In this regard, the search for combined approaches that allow influencing different pathogenetic links of the disease is relevant.