Calculation of pharmacokinetic parameters and toxicity of 5-methoxypyrimidine derivatives

Abstract

. Heterocyclic compounds with a pyrimidine core are characterised by a wide range of biological activity and significant potential for medical applications as therapeutic agents, in particular, they exhibit pharmacological activity within the central nervous system, and antitumor, antiviral, antibacterial, and antimalarial activity have been reported. Despite the wide range of synthetic drugs on the pharmaceutical market, the search for new biologically active compounds remains relevant, while in silico prediction methods allow the selection of potentially effective molecules at an early stage.