Влияние производных (2-оксоиндолинилиден-3)-уксусной кислоты и спироциклического производного оксиндола на поведенческие реакции и морфологические изменения головного мозга на моделях церебральной ишемии

Abstract

The influence of original (2-oxoindoline-3-oxoindoliniliden-3) acetic acid derivatives on survival rate has been studied on the models of bilateral carotid occlusion and gravitational ischemia. Only the bilateral carotid occlusion model was used to study the influence of spirocyclic derivative of oxindole. It has been found experimentally that studied substances increase survival rate on animal ischemic stroke models. The compounds decrease neurological deficit in the postischemic period (according to the open field test). The brains of the animals that undergone the ligation of both carotid arteries was morphologically examined. The cerebroprotective effect of investigated compounds was confirmed by histological study which had shown destructive changes diminution. New compounds considerably excel pyracetam (200 mg/kg dosage) in the impact on survivability, intensity of neurological deficit and ability to decrease the brain destructive changes caused by acute cerebral circulatory disturbances.