Дослідження психотропних властивостей потенційних рослинних антиконвульсантів

Abstract

Изучены психотропные свойства сухих экстрактов дымянки Шлейхера и базилика камфорного, которые в предыдущих исследованиях проявили значительную противосудорожную активность. Установлено, что сухой экстракт дымянки Шлейхера, в отличие от сухого экстракта базилика камфорного, обладает выраженными анксиолитическими и умеренными антиамнестическими свойствами. Кроме того, исследуемые экстракты не влияют на поведение, уровень депрессивности, а также на мышечный тонус и координацию движений экспериментальных животных.

The study investigated the influence of the perspective herbal anticonvulsants – fumitory (Fumaria schleicheri Soy.-Willem.) and basil (Ocimum basilicum L.) dry extracts – on behavioral reactions, level of depression and anxiety, memory, muscle tone and coordination of movements using different experimental models. It was revealed that fumitory dry extract (100 mg/kg) don’t influence on mouse behavior in combined open field test and on the depression level in tail suspension test. Anxiety reduction in animals treated with fumitory dry extract is indicated by an increase in the total time spent in the open arms, an increase in entries into the open arms and the latency period of the first entrance to the closed arm in elevated plus maze test. It was proven that fumitory dry extract don’t have a negatively impact on muscle tone and coordination of movements in rotating rod method. The results of the conditional reaction of passive avoidance test have shown the absence of influence of fumitory dry extract on memory in intact animals and moderate nootropic activity on the model of scopolamine-induced amnesia. Basil dry extract (100 mg/kg) has a tendency to increase the locomotor and research activity, but it doesn’t influence on emotional sphere, depression and anxiety level, memory, muscle tone and coordination of movements. In general basil dry extract doesn’t have anxiolytic and nootropic properties, unlike fumitory dry extract in the same dose. Thus, the fumitory dry extract at a dose of 100 mg/kg may considered to be a potential anticonvulsive medicine with a number of additional useful psychotropic properties.