Research on the Choice of an Emulsifier in the Development of the Composition of Tamsulosin Hydrochloride Suppositories.

Abstract

The article is devoted to the choice of the type and concentration of the emulsifier in the composition of Tamsulosin Hydrochloride suppositories on the basis of biopharmaceutical research. As a result of the experiment a complex emulsifier Lanette SX was chosen. The optimum surfactant concentration of 5 % provides the highest affinity of the active substance to the hydrophilic membrane of the rectum and contributes to the better release of Tamsulosin Hydrochloride suppositories. The increase of the concentration of emulsifier from 5% to 7% does not significantly affect the increase of Tamsulosin release and is therefore inappropriete. As a result of the studies it was found that the introduction of some emulsifier into the suppository basis reduces the surface tension of the former and contributes to the better release of the active substance.