Исследование церебропротекторного влияния 2‑метил‑3‑фениламинометилхинолин‑4‑она на изменения тинкториальных свойств нейронов в головном мозге крыс после черепно-мозговой травмы

Abstract

The article presents the results of morphological study of the effect of 2-methyl-3-phenylaminomethylquinolin-4-one (atristamine) on changes of tinctorial properties of neurons in the sensorimotor cortex (SMC) of the cerebral hemispheres and the cerebellar cortex of rat brain in experimental traumatic brain injury (TBI) conditions. It has been shown that significant changes in the structural and functional organization of the SMC and the cerebellar cortex develop in the context of the model pathology. When applying atristamine in dose 100 mg/kg to correct disorders caused by head injury, the normalization of the ratio of main types of neurons in the SMC to the ntact control level has been observed. The severity of chromatolysis and destructive changes in the Purkinje cells of cerebellum cortex after administration of atristamine was reduced, and the order of cells was remained. Analysis of the results shows that the cerebroprotective effect of atristamine (100 mg/kg) after TBI is more pronounced as compared to the reference drug piracetam (400 mg/kg).