A study of the influence of solvents on crystallographic characteristics of local anesthetics

Abstract

Esters of para-aminobenzoic acid (PABA) – benzocaine and substituted amides – lidocaine and trimecaine are used in suppositories as substances with anesthetics effect. When benzocaine is used to reduce pain the effect develops for 1 minute after applying of rectal dosage forms and lasts for 20-30 minutes. The maximum effect of lidocaine is manifested within 15-30 minutes after using the medications. Trimecaine is absorbed rapidly and has a period of action of 60 minutes, but in the presence of inflammation, it is possible to decrease the anesthetic activity. The above local anesthetics have a low toxicity, which is an essential aspect in the formation of medications.