Synthesis of new Mannich bases containing 1,2,4-triazole and piperidine moiety

Abstract

The 1,2,4-triazole nucleus forms the basis of a series of compounds of both therapeutic and chemical interest. 1,2,4-triazole derivatives possesses antiviral, antibacterial, antitumor, antidepressant, antihypertensive activity etc. Substituted 1,2,4-triazole-3-thiones can be used as substrats containing active hydrogen for Mannich reaction. Mannich reaction is important for the construction of nitrogen-containing compounds. The literature studies enlighten the fact that Mannich bases are very reactive and recognized to possess potent diverse activities like anti-inflammatory, antibacterial, anti-HIV, antimalarial, antitubercular, analgesic, antipsychotic activities and so forth. In view of this, the aim of our work was to synthesize new Mannich bases in order to find biologically active substances.