Features of frequency distribution of immunogenetic markers of class 1 hla in children with type 1 diabetes in combination with thyroid pathology introduction

Abstract

has been established [1] that the genetic base of diabetes mellitus (DM) type 1 is on 70% determined by the HLA (Human Leukocyte Antigens) genes. No other genetic area alone determines the risk of developing a disease compared to the HLA system. According to the available data [2], autoimmune diseases of the thyroid gland and type 1 DM represent autoimmune syndromes of the unknown etiology with common immunological defects (target cells, thyrocytes and cells of the islets of Langerhans, excessively produce some proteins encoded by the HLA system – HLA of class 1, HLA of class 2 and transporter associated with antigen processing protein (TAP-1)).