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Название: | Synthesis of 2-(4-aryl(adamantyl)-2-phenylіmіnothіazol-3-yl)-ethanol derivatives and prediction of their biological activity |
Авторы: | Yeromina, H. O. Drapak, I. V. Perekhoda, L. O. Yaremenko, V. D. Demchenko, A. M. |
Ключевые слова: | 1,3-thiazole derivatives;synthesis;spectral characteristics;«drug-likeness»;virtual screening |
Дата публикации: | 2016 |
Библиографическое описание: | Synthesis of 2-(4-aryl(adamantyl)-2-phenylіmіnothіazol-3-yl)-ethanol derivatives and prediction of their biological activity / H. O. Yeromina, I. V. Drapak, L. O. Perekhoda, V. D. Yaremenkom, A. M. Demchenko // Der Pharma Chemica. – 2016. – № 8 (3). – P. 64-70. |
Краткий осмотр (реферат): | The synthesis of new 2-(4-aryl(adamantyl)-2-phenylіmіnothіazol-3-yl)-ethanol derivatives has been carried out. The structures and purity of synthesized compounds were verified on the basis of elemental analysis, 1Н NMRspectroscopy and chromatography-mass spectrometry. To optimize the pharmacological screening of 2-(4-aryl(adamantyl)-2-phenylіmіnothіazol-3-yl)-ethanol derivatives «drug-like» parameters have been calculated and simulation of biological properties has been done. It was established that 13 synthesized compounds comply with Lipinski's Rule of Five and can be recommended for experimental biological tests. Based on data PASS-prediction as priority directions for experimental trials screening for anti-ischemic and anti-inflammatory activity has been chosen. The most perspective substances for experimental biological tests were elected. |
Описание: | The synthesis of undescribed in the literature 2-(4-R-aryl(adamantyl)-2-phenylіmіnothіazol-3-yl)-ethanol derivatives was сarried out for the purpose of searching for new biologically active compounds and the structure of synthesized compounds were confirmed by elemental analysis, 1Н NMR- and chromatomass-spectra |
URI (Унифицированный идентификатор ресурса): | http://dspace.nuph.edu.ua/handle/123456789/21536 |
Располагается в коллекциях: | Наукові публікації кафедри медичної хiмiї |
Файлы этого ресурса:
Файл | Описание | Размер | Формат | |
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DPC-2016-8-3-64-70.pdf | 125,53 kB | Adobe PDF | Просмотреть/Открыть |
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