Research of rheological properties of medicinal syrup for oral use

Abstract

ABSTRACT The aim of the present research was to investigate the rheological properties of the medicinal syrup for oral administration with glucosamine hydrochloride and levocarnitine. Matherials and methods: Coefficient of the dynamic flow (at shear rates of 3,49 and 10,3 s -1, as well as at shear rates of 27.2 and 149.0 s-1), mechanical stability, the index of destruction and restoration were studied. The rheological (structural-mechanical) properties of the samples were determined using a Rheolab QC rotaryviscometer (AntonPaar, Austria) with coaxial cylinders CC27 / S-SN29766. Therheologicalparameters werestudiedat the temperature 20±0,5 °С. Results: Itisestablishedthatthesyrup hasweaklyexpressedplasticviscousandthixotropicproperties (the hysteresisareaforthesyrupis 1710.19 Pas/s). Such results characterize the system as a reopex. Conclusions:Theresultsofthestudy enables classification of the research objectassystemwith a lowdegreeof fluidity. Such dependenceistypical forsystemsofthe Newtonian typeof flow andcharacterizes thesyrupunder investigation as a weaklystructureddispersesystem.