Search for Novel Fluoroquinolone Hybrids and Assessment of their Antimicrobial Activity

Abstract

Four generations of fluoroquinolones (FQs) are utilized in modern clinical practice due to their wide spectrum of action, high bioavailability and tolerability. Still, their misuse and overuse are leading to the appearance of resistant strains and this issue becomes more and more pressing. Therefore, medicinal chemists design new molecules based on the known core structures to increase activity and combat resistance. Thus, our research was aimed at synthesis and study of antibacterial properties of hybridized fluoroquinolones. Such modifications may proceed in different directions and combination with small heterocycles is a promising way for the creation of new antimicrobials