Rational design of multimodal antiepileptic agents based on the tetrazole framework of cenobamate

Abstract

Epilepsy is a complex polyetiological neurological disorder characterized by a chronic predisposition of the brain to generate paroxysmal electrical activity, leading to recurrent seizures and cognitive–behavioral impairments. The pathophysiological basis of the disease lies in the imbalance between excitatory (glutamatergic) and inhibitory (GABAergic) processes in neuronal networks, resulting in neuronal hyperexcitability and impaired synaptic plasticity