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Title: | Synthesis and alkylation of 1-aryl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-ones as possible anticonvulsant agents |
Authors: | Severina, A. I. Georgiyants, V. A. Shtrygol', S. Yu. Kavraiskyi, D. P. |
Keywords: | synthesis;pyrazole;alkylation;acetamides;activity prediction |
Issue Date: | 2015 |
Publisher: | Scholars Research Library |
Bibliographic description (Ukraine): | Synthesis and alkylation of 1-aryl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-ones as possible anticonvulsant agents / A.I. Severina, V.А. Georgiyants, S.Yu. Shtrygol’, D.P. Kavraiskyi // Der Pharma Chemica. – 2015. – Vol. 7, №11. – P. 43–48. |
Abstract: | The synthesis of 1-(4-bromophenyl)- and 1-(2-chlorophenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4-one as possible anticonvulsant agents was planned. It was carried out by the interaction of the corresponding phenylhydrazine hydrochloride with ethyletoxymethylencyanocetate with a further heating of obtained 5-аmino-1- аryl-1H-pyrazole-4-carboxylate in excess of formamide. The direction of reaction of 1-aryl-1,5-dihydro-4Hpyrazolo[ 3,4-d] pyrimidine-4-one with N-arylsubstituted α-chloracetamides, 2-chloro-1-(4-arylpiperazine-1-yl)- ethanone and 2-chloro-N-(4-chlorobenzyl)acetamide in the presence of DMFA-NaHCO3 had been investigated. Using the data of NMR and NOESY spectroscopy it was found out that reaction is selectively performed at 5 position of pyrazolo[3,4-d]pyrimidine system. Due to preliminary prognosis of biological activity pharmacological screening of substances synthesized as possible anticonvulsant agents on the penthyltetrazole seizures was planned |
URI: | http://dspace.nuph.edu.ua/handle/123456789/10817 |
Appears in Collections: | Наукові публікації кафедри фармакологiї та фармакотерапії |
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