Formulation development of anti-stress compressed lozenges using a fractional factorial Latin cube design and ANOVA approach

Abstract

Oromucosal administration of drug offers several advantages over the traditional oral route. One of the most important among them is the ability of a drug to be rapidly absorbed through the oral mucosa and directly enter the systematic circulation, avoiding in such a way (at least, partially) the first-pass metabolism in the gastrointestinal tract.