Development of methods of boric acid quantitative determination in experimental ointment

Abstract

A method for the quantitative determination of boric acid by alkalimetric method in mild experimental dosage forms is proposed. The aqueous boric acid solution was titrated with 0.1 M sodium hydroxide solution in the presence of mannitol to establish the end point of the titration by an indicator method using phenolphthalein solution. When studying the validation characteristics, we calculated the complete uncertainty of the analytical methodology, determined the parameters of linearity, accuracy and precision. According to the results of the study, it was found that the alkalimetric method is linear in concentrations from 80% to 120% of the selected concentration according to the method (correlation coefficient 0.9993 ≥ 0.9981). The method is precise because the value of the relative confidence interval Δ.% 1.19 ≤ 1.60% is found and is correct, as the criterion of uncertainty of systematic error 0.31% is fulfilled. The developed method of quantitative determination of boric acid by alkalimetric method can be used to analyze the experimental soft dosage form and study the stability of the dosage form. The obtained results are metrologically certified.