Selection of flavour additives and method of their introduction in the composition of compressed medicated chewing gums

Abstract

During the development of drugs for oral use, great attention is paid to their taste characteristics. Dosage forms (DF) of that type of drugs include medicated chewing gum (MCG), the release of APIs from which occurs in the mouth in the process of chewing. Therefore, in substantiating the composition of drugs in this DF, the main issue remains to give them a pleasant taste.It is known that the organoleptic properties of drugs are perceived by man comprehensively and represent a combination of taste and smell. So not only sweeteners but also flavour additives are referred to corrective substances – they mask the unpleasant smell of APIs or complement the sweetener taste