Please use this identifier to cite or link to this item: http://dspace.nuph.edu.ua/handle/123456789/21045
Title: Synthesis and antimicrobial activity of Bis-Derivatives of 3a′, 6a′Dihydro-2'H-Spiro[Indole-3,1'-Pyrrolo[3,4-c]Pyrrole]-2,4',6'(1H, 3'H, 5'H)-Trione
Authors: Redkin, R. G.
Syumka, E. I.
Shemchuk, L. A.
Chernykh, V. P.
Редькін, Р. Г.
Сюмка, Е. И.
Сюмка, Є. I .
Шемчук, Л. А.
Черних, В. П.
Черных, В. П.
Keywords: isatins;α-amino acids;2-oxindoles;bis-spirocyclic systems;bis-maleimides;1,3-cycloaddition;antimicrobial activity
Issue Date: 2017
Bibliographic description (Ukraine): Synthesis and antimicrobial activity of Bis-Derivatives of 3a′, 6a′Dihydro-2'H-Spiro[Indole-3,1'-Pyrrolo[3,4-c]Pyrrole]-2,4',6'(1H, 3'H, 5'H)-Trione / / R. G. Redkin, E. I. Syumka, L. A. Shemchuk, V. P. Chernykh // Journal of Applied Pharmaceutical Science. - 2017. - Vol. 7 (06). - Р. 69-78.
Abstract: The interaction of isatins, α-amino acids and 1,6-bismaleimidohexane has been studied. It was found that for 1'R3-2'-R2-3'-R1-5'-(6-{1'-R3-2'-R2-3'-R1-2,4',6'-trioxo-1,2,3',3'a,4',5',6',6'a-octahydro-2'H-spiro[indole-3,1'pyrrolo[3,4-c]pyrrole]-5'-yl}hexyl)-1,2,3',3'a,4',5',6',6'a-octahydro-2'H-spiro[indole-3,1'-pyrrolo[3,4-c]pyrrole]2,4',6'-triones were formed through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and some α-amino acids with dipolarophile 1,6bismaleimidohexane. This method has the advantages of mild reaction conditions, high atom economy and excellent yields. The most suitable conditions for this reaction are boiling alcohol-water medium. The obtained compounds showed a weak selective antimicrobial activity for the Micrococcaceae family.
URI: http://dspace.nuph.edu.ua/handle/123456789/21045
Appears in Collections:Наукові публікації В. П. Черних

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