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http://dspace.nuph.edu.ua/handle/123456789/21045| Title: | Synthesis and antimicrobial activity of Bis-Derivatives of 3a′, 6a′Dihydro-2'H-Spiro[Indole-3,1'-Pyrrolo[3,4-c]Pyrrole]-2,4',6'(1H, 3'H, 5'H)-Trione |
| Authors: | Redkin, R. G. Syumka, E. I. Shemchuk, L. A. Chernykh, V. P. Редькін, Р. Г. Сюмка, Е. И. Сюмка, Є. І. Шемчук, Л. А. Черних, В. П. Черных, В. П. |
| Keywords: | isatins;α-amino acids;2-oxindoles;bis-spirocyclic systems;bis-maleimides;1,3-cycloaddition;antimicrobial activity |
| Issue Date: | 2017 |
| Bibliographic description (Ukraine): | Synthesis and antimicrobial activity of Bis-Derivatives of 3a′, 6a′Dihydro-2'H-Spiro[Indole-3,1'-Pyrrolo[3,4-c]Pyrrole]-2,4',6'(1H, 3'H, 5'H)-Trione / / R. G. Redkin, E. I. Syumka, L. A. Shemchuk, V. P. Chernykh // Journal of Applied Pharmaceutical Science. - 2017. - Vol. 7 (06). - Р. 69-78. |
| Abstract: | The interaction of isatins, α-amino acids and 1,6-bismaleimidohexane has been studied. It was found that for 1'R3-2'-R2-3'-R1-5'-(6-{1'-R3-2'-R2-3'-R1-2,4',6'-trioxo-1,2,3',3'a,4',5',6',6'a-octahydro-2'H-spiro[indole-3,1'pyrrolo[3,4-c]pyrrole]-5'-yl}hexyl)-1,2,3',3'a,4',5',6',6'a-octahydro-2'H-spiro[indole-3,1'-pyrrolo[3,4-c]pyrrole]2,4',6'-triones were formed through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and some α-amino acids with dipolarophile 1,6bismaleimidohexane. This method has the advantages of mild reaction conditions, high atom economy and excellent yields. The most suitable conditions for this reaction are boiling alcohol-water medium. The obtained compounds showed a weak selective antimicrobial activity for the Micrococcaceae family. |
| URI: | http://dspace.nuph.edu.ua/handle/123456789/21045 |
| Appears in Collections: | Наукові публікації В. П. Черних |
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